The early bone density machines in the 1970's and early 1980's all used different kinds of units, so results were reported in Zscores to allow comparisons to normal people. Later bone density was measured in large populations and the Zscores were compared to the general population and not just to healthy people. Show
In the 1990's most people were using DEXA machines, which report units in g/cm2. But when the bone density machines became commercial, the different companies would not agree on a standard measurement. A person would be about 6% higher on a Lunar machine than on a Hologic machine, even though both said they were reporting g/cm2. If the companies would have used the same standards, then we could always just look at the plain bone density in g/cm2, just like we look at cholesterol in mg/dl or weight in kg. Unfortunately, that did not happen. Instead, the Tscore was invented. Tscores are not used (to my knowledge) in any other aspect of clinical medicine, and for 20 years they have caused trouble and confusion. Some investigators have tried, unsuccessfully, to establish a "standardized" unit of mg/cm2. Equations have been published to convert Hologic, Lunar, or Norland measurements to standardized units. The NHANES study also reported the standardized units. The equations and converters are on the page about standardization. The reference ranges are also problematic. Currently the NHANES study (Looker) is used for the hip reference data by everybody. The different machines still use their own reference data sets for the spine because the spine was not included in the NHANES study. ZscoresZscores can be used to compare a measurement to a reference value. The zscore is the number of standard deviations away from the average value of the reference group. This reference group usually consists of people of the same age and gender; sometimes race and weight are also included. This table shows how zscores correspond to percentiles. The percentile is the percent of people in the population who have a lower bone density. A person who is average has a Zscore of zero and is at the 50th percentile. If the Zscore is 0.84 then 20% of people have a lower bone density. Pediatricians use percentiles to interpret the height of a child. A child at the 5th percentile (same as Zscore of 1.65) is short for his or her age, and one at the 75th percentile is somewhat taller than average (Zscore of 0.68). The Zscore does not tell how tall a child is, because the average child gets taller as she gets older. On the other hand, if you know that a child is 40" tall, it does not mean anything unless you also know his age. You must know both the age and the percentile to know if this is a healthy height. For bone density, the Zscore will tell you if the bone density is close to the average value for the person's characteristics such as age, race and gender, but that still does not tell you if the bone is strong. Elderly white women have weak bones even if the bone density is average. Calculation of zscoresYou need to have a table of reference values showing the mean (average) and standard deviation (SD) for the age, gender, race, skeletal site, and densitometer measurement units. I call this the "expected BMD". The following table gives values from NHANES dataset. Then you use the formula: Zscore = (Patient's BMD  expected BMD) / SD To calculate BMD if you know the Zscore, use the same equation rearranged:BMD = expected BMD + ( Zscore x SD ) Total hip, standardized units, mg/cm2White WomenWhite menBlack WomenBlack MenAgeBMDSDBMDSDBMDSDBMDSD2595512310551461040135118917135945130103814410171421141166459201361002140103416010941625587613999014397317510721856580914096915789015410271687574012992815183815498417385679135859161723146933194For example, a white woman aged 55 with BMD of 850 has a Zscore of (850876)/139 = 0.18A black man aged 55 with BMD of 850 has a Zscore of A 65 year old white woman with a A 25 year old white woman with a Relationship between zscore and fracture riskEpidemiologists measure bone density in a large population, then wait to see who fractures their bone. Using statistical models, they calculate the risk of fracture for each standard deviation below the mean for the age, race and gender. This is the "relative risk". These risks depend on the population, skeletal site of measurement, technique of measurement, and type of fracture. For example, DEXA of the hip has a relative risk of about 2.5 for each standard deviation for predicting hip fracture; therefore, a person with a zscore of 1 has 2.5 times the chance of a hip fracture compared to a woman with Zscore of zero (average). You still don't actually know what the fracture risk is unless you also know the risk of an average person, which depends on age, race, gender and other factors not related to the bone density. This topic is discussed in greater detail in the section about BMD and fracture risk. TscoresConverting the BMD to the Tscore is like converting the temperature from degrees Fahrenheit to degrees centigrade:The reference BMD and standard deviation (SD) are to a young person instead of a person the same age as the patient. The reference BMD depends on: For example, this "thermometer" shows the values measured by a Hologic densitometer at the total hip in a Caucasian woman from the NHANES study. The reference BMD is 0.942 and the reference standard deviation is 0.122. When the Tscore is 1, the bone density is 0.820 no matter how old the person is. The white numbers are at the average values for that age. The Tscore does not necessarily have to compare people of the same race or gender. A black man can have a Tscore compared to black men, white men, or white women, depending on which reference BMD is used. This gets confusing because the bone density machines in the USA report the Tscore based on race and gender but the WHO calculator bases it on the values for white women. Notice that when the Tscore is zero (average peak bone mass) the bone density is highest in black men and lowest in white women. At very low Tscores, however, the bone density is the same. This is due to differences in the standard deviations of the young populations. Convert Tscores in men and nonCaucasian races for DEXA femoral neckThe newest WHO fracture risk calculator uses Tscores based on Caucasian women for all the risks. Here is a converter, based on the NHANES database at the femoral neck. It gives the whitefemalereferentTscore when you enter another sexandracereferentTscore: This shows the derivation of the equations. (The reference values are a little different from those above because this is for the femoral neck and not the total hip) Tscore of femoral neck is lower than total hip in menFor older men, the Tscore for the femoral neck will be lower than the Tscore for the total hip. This graph shows the data from the NHANES study, using the young male values as the reference value. The graph shows the Tscores for average men. In other words, for all these points the Zscore is zero. For example, a 65year old man with a Tscore of 1.1 at the femoral neck would have the SAME risk of fracture as a 65year old man with a Tscore of the total hip of 0.6. The graph shows the Tscores, calculated from young female reference values, for average men and women from a large metaanalysis (Johnell, ASBMR abstract 2005). Converting T scores to and from ZscoresYou must know the age, gender and race and skeletal site and have a reference table of average Tscores. The values shown here are all using race and gender references at the total hip from the NHANES database. This works because the standard deviations are about the same for all ages. Zscore = Tscore  Reference TscoreTscore = Zscore + Reference TscoreExamples: 85yrold white woman with Tscore of 2.25 has Zscore of 0 65yrold white man with Tscore of 0.3 has Zscore of +0.3 55yrold black woman with Zscore of 1 has Tscore of 1.5 55yrold black woman with Zscore of +1 has Tscore of +0.5 For 25yrolds Zscore and Tscore will be the same. Otherwise the Tscore is always worse than the Zscore. The exception is when weight is included to calculate the Zscore, which I think should not be done. Some common misunderstandings1. The Tscore can predict fracture risk better than the Zscore.Neither one of these scores can predict the fracture risk unless you also know the age. Because the Tscore and Zscore can be converted back and forth, you predict fractures equally with either one. 2. A measurement that gives lower Tscores has better ability to predict fracturesIf a measurement has lower Tscores in older people, it could be due to a faster decline with aging (as in the case of QCT or femoral neck bone density). It also could be due to smaller standard deviations in the young population. The fracture rates go up steeply with age, so any test that is closely related to age will be able to predict that an older person has more fractures than a young person. But clinically we want to know whether the test can discriminate between those of the same age who will or won't fracture. So if a person has a QCT measurement 1SD lower than average for age (ie, Zscore of 1) her risk of fracture is quite similar to a person with DEXA Zscore of 1. The Tscore of the QCT, however, will be much lower than of DEXA. 3. The risk of a hip fracture increases 2.5 times for every SD decrease in thehip Tscore, so the fracture risk is 2.5 times the Tscore compared to anaverage person the same age.The standard deviations don't change very much with age, so the risk per SD will be the same using Tscore or Zscore. The fracture risk, however, should be compared to a person the same age with a Tscore of zero, not an average person. 4. The Tscore of the femoral neck is interchangeable withthe Tscore at the total hipThis is approximately true for women, but not for men. The fracture risk per Zscore is similar for the femoral neck and the total hip, but the conversion formulas from the Tscore at the total hip are not the same as those from the femoral neck. What is a normal TFor postmenopausal women and men age 50 years and older, the Tscore is the number that is used for diagnostic classification, as follows: A Tscore of 1.0 or above is normal bone density.
What is the desirable range for bone density TAs shown in the table below, a Tscore between +1 and −1 is considered normal or healthy. A Tscore between −1 and −2.5 indicates that you have low bone mass, although not low enough to be diagnosed with osteoporosis. A Tscore of −2.5 or lower indicates that you have osteoporosis.
Can you improve your bone density TCan I improve my Tscore? In some cases, a Tscore can be improved. However, it depends on where your score falls within the risk range and your lifestyle. Building up your bone density may involve taking medications as prescribed, eating plenty of foods that contain calcium and vitamin D, and exercising regularly.
What is considered a low TA normal Tscore falls between +1 and 1. Scores between 1 and 2.5 indicate low bone density, also called osteopenia. A Tscore of 2.5 or lower indicates an established case of osteoporosis.
