Acetaminophen / dextromethorphan / phenylephrine is also known as: Alka-Seltzer Plus Maximum Strength Day Cold & Flu Liquid Gels, Alka-Seltzer Plus Multi-Symptom Cold & Flu Day Liquid Gels, Alka-Seltzer Plus Severe Sinus Congestion & Cough Liquid Gels, BC Cough & Cold, Comtrex Cold & Cough, Comtrex Cold and Cough Maximum Strength, Contac Complete Cough, Cold & Flu Extra Strength, Day Relief PE, Day Time Multi-Symptom Cold/Flu Relief, Daytime Cold & Flu, Little Colds Multi-Symptom, Mapap Cold Formula, Mucinex Fast-Max Congestion & Headache, Multi Symptom Cold (Day Formula), Neocitran Non Drowsy Extra Strength Cold and Flu, Robitussin Cold + Flu (Daytime), Robitussin Peak Cold Daytime Cold + Flu, Theraflu Daytime Severe Cold & Cough, Theraflu Multi-Symptom Severe Cold with Lipton Flavors, Theraflu Warming Relief Daytime Severe Cold & Cough, Tylenol Cold Max Day, Tylenol Plus Children's Cold & Cough, Vicks Dayquil Cold & Flu Relief, Vicks Dayquil Cold & Flu Symptom Relief Plus Vitamin C, Vicks Nature Fusion Cold & Flu Multi-Symptom Relief Show Acetaminophen / dextromethorphan / phenylephrine Pregnancy WarningsThe manufacturer makes no recommendation regarding use during pregnancy. AU TGA pregnancy category: B2 Comments: Animal studies are not available for the combination product. There are no controlled data in human pregnancy. Acetaminophen: Routinely used during all stages of pregnancy, it appears safe for short-term use. This drug crosses the placenta. Dextromethorphan: Available data does not indicate a major teratogenic risk, and a survey study did not show a relationship with congenital malformations. Phenylephrine: A monitoring study including 1249 mother-child pairs that had first trimester phenylephrine exposure showed an increase in malformation, with association greater with minor defects than major defects (8 eye and ear defects, 6 syndactyly, 4 preauricular skin tags, and 3 clubfoot cases); 4149 any time pregnancy exposures were associated with 15 congenital dislocation of the hip, 6 umbilical hernia, and 4 other musculoskeletal defects. Placental transfer is likely with phenylephrine's low molecular weight (about 167). AU TGA pregnancy category B2: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage. US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out. See references Acetaminophen / dextromethorphan / phenylephrine Breastfeeding WarningsThe manufacturer makes no recommendation regarding use during lactation. Excreted into human milk: Yes (acetaminophen) /Data not available (dextromethorphan, phenylephrine) Comments: See references References for pregnancy information
References for breastfeeding information
Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Is AlkaWhat about taking Alka-Seltzer while pregnant? Remedies containing aspirin (such as Alka-Seltzer) should be avoided during pregnancy. Aspirin may be listed on a label as salicylate or acetylsalicylic acid.
Which antacid is safe during pregnancy?Antacids, H2RAs, and PPIs are safe for use in pregnancy, so if life-style modifications fail to manage GERD symptoms, these medications can be added to the antiemetic treatment regimen.
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