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Acetaminophen, the popular pain reliever known by the brand name Tylenol, can raise blood pressure when taken regularly, according to a study in the Feb. 7, 2022, issue of Circulation. Earlier research had hinted at this problem, so investigators designed a clinical trial to clarify the risk. They recruited 110 people with high blood pressure and randomly assigned them to take 1,000 milligrams (mg) of acetaminophen or a placebo four times a day for two weeks. (The 4,000-mg daily dose is the generally recommended maximum daily amount for healthy adults.) After a two-week wash-out period, those taking acetaminophen were switched to taking the placebo and vice versa for an additional two weeks. While people were taking acetaminophen, their blood pressure rose by an average of 5 points, the researchers found. Experts have long known that other common pain relievers — nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin, Advil) and naproxen (Aleve, Naprosyn) — can also raise blood pressure. The take-home message? If you need a pain reliever, take the lowest possible dose for the shortest possible time. Image: © Dejan Marjanovic/Getty Images As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
Clinical Trial Effect of high-dose ibuprofen on 24-hour blood pressure in healthy womenJ M McKenney et al. Drug Intell Clin Pharm. 1987 Jun. AbstractThe nonsteroidal antiinflammatory drug (NSAID) indomethacin has been shown to increase blood pressure in normotensive individuals. The effect of other NSAID on blood pressure has not been as well studied. We evaluated the effects of ibuprofen, an NSAID currently available without a prescription, on 24-hour ambulatory blood pressure in ten young, healthy, normotensive women. Using a randomized, crossover, double-blind design, subjects received ibuprofen 800 mg and a placebo identical in appearance to ibuprofen three times a day for eight days with a washout period between regimens. Subjects were instructed to follow a no-added salt diet during the study. Twenty-four-hour blood pressure monitoring and 24-hour urine collection for prostaglandin E2, creatinine, and sodium were performed on days 1 and 8 of each study week. Tablet counts and a 40 percent reduction in urinary prostaglandin E2 documented compliance with ibuprofen. Ibuprofen had no significant effect on systolic or diastolic blood pressure at any hour during the 24-hour period. Mean blood pressure for the 24-hour period was 112/73 and 111/73 mm Hg on day 1 and 111/73 and 112/73 mm Hg on day 8 for placebo and ibuprofen, respectively. We conclude that ibuprofen at doses as high as 2400 mg/d for up to seven days has no effect on blood pressure in normotensive women. Further studies are needed in hypertensive subjects. Similar articles
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What are the side effects of taking Advil PM every night?Common side effects may include:. drowsiness;. day-time drowsiness, dizziness, "hangover" feeling;. upset stomach, heartburn, diarrhea, constipation;. dry mouth, nose, or throat;. blurred vision;. mild itching or rash; or.. ringing in your ears.. How much does Advil raise BP?All nonsteroidal antiinflammatory drugs (NSAIDs) in doses adequate to reduce inflammation and pain can increase blood pressure in both normotensive and hypertensive individuals [1]. The average rise in blood pressure is 3/2 mmHg but varies considerably [2-4].
Is it OK to take Advil if you have high blood pressure?You should not use ibuprofen if you have high blood pressure, unless your doctor has explicitly told you that you can. Ibuprofen can also impair the effectiveness of common blood pressure medicines like ace inhibitors (such as Lotensin, Capoten, and Vasotec) and beta blockers (such as Coreg, Lopressor, and Corgard.)
Can you take ibuprofen PM with high blood pressure?Unless your doctor has told you it's OK, do not use over-the-counter ibuprofen, naproxen sodium, or ketoprofen for pain relief. Instead, use a painkiller less likely to increase your blood pressure, like aspirin or acetaminophen. Use as directed.
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Can advil pm cause high blood pressure
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